How to Slow Aging (and even reverse it)

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14.12.2019
Veritasium

Veritasium

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21.07.2010
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Описание видео:

Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging. Thanks to LastPass for sponsoring this video. Click here to start using LastPass: 🤍ve42.co/VeLP What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well. To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging. Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment. Special thanks to: Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To" Assistant Professor David Gold Noemie Sierra (for polyp images) Genepool Productions for telomere animations from Immortal: 🤍ve42.co/immortal Epigenetics animations (DNA, histones, methylation etc) courtesy of: 🤍wehi.tv Animation: Etsuko Uno Art and Technical Direction: Drew Berry Sound Design: Francois Tetaz & Emma Bortignon Scientific Consultation: Marnie Blewitt Courtesy of Walter and Eliza Hall Institute of Medical Research Filming, editing and animation by Jonny Hyman and Derek Muller Music from 🤍epidemicsound.com "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed" Additional music by Kevin MacLeod from 🤍incompetech.com "Marty Gots a Plan"

Кадры из видео
How to Slow Aging (and even reverse it)
How to Slow Aging (and even reverse it)
How to Slow Aging (and even reverse it)
How to Slow Aging (and even reverse it)
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Комментарии пользователей:
Walter's Phantom
2023-01-30 03:45:21

Humans are not meant to be immortal. But this is interesting! thank you...

aramisdjv
2023-01-29 17:24:08

What is up with that NMN molecule?

Ronald
2023-01-29 14:50:18

what if I do bodybuilding? then what?

Matrus Doubt
2023-01-29 09:14:50

The brighter candle burns shorter... suffer much and live long or suffer little and live short. That's what I think is the dynamics

IKILL MELOL
2023-01-27 19:02:06

You can tweak the DNA and use the immune system to clear wrinkles, Scars, Moles, Even palm lines. I know because that's happening to me at 48 so it's possible. 😁

Sean L. Slater
2023-01-26 15:57:46

I think we should try to be come immortal!!! I will be able to visit my mother and aunts and uncles.

Ibraheem alotaibi
2023-01-26 15:40:26

so theoretically speaking, having an abundance of Nano cells that act like Stem cells can potentially stop aging?

Canuto Imperial
2023-01-25 03:27:33

But we aging at almost the same time also means that there’s a preset cycle or a wear timeline.

GeraldPUR
2023-01-24 12:22:23

I can only wish for this and I'm 49 now in good health. Those concerns will disappear as soon as we start taking to the stars 🌟

Ecoder EliteCoder
2023-01-24 11:55:57

so in other word, how to increase your HGH to enjoy long life and better strength.

SL 74
2023-01-24 11:36:51

Honestly just live a short and happy life longer life will cause nothing but misery on different levels and nature will develop some strategy to drive us extinct

SL 74
2023-01-24 11:34:43

The thing is keep up high growth hormone levels throughout your life and u wil never die

Rachel Stark - Magnesium girl
2023-01-24 02:00:12

Not sure mice got to the top of the food chain from eating dense meats. Would rather see conclusive evidence in humans as those with a high meat diet live longer and more healthily according to a recent huge study from italy.

GMONEY-TEX
2023-01-24 01:36:47

Professor Sinclair is actually 450 years old....

Matteesside
2023-01-23 18:20:21

Have you revisited this ? 3 years old now. Would be interesting

woloabel
2023-01-22 22:46:34

(On Sunday January 22, 2023). PhD David Sinclair and Derek Muller have a common topic of Epigenetics and the Role of Ageing Therein. Unfortunately, a premature approach but a great and even promising ideation of Geriatric/Gerontological Proportions (Rather Eugenics but somewhat negative Press onto this Term lately), where the Genome and the underlying Proteins (Histones and Chemical Reactions Therein) have the most notorious propensity of actually dispensing Entropy (Biochemists might prefer mediating senescence and what not) or the inherent disorder Post Developmental Perfection, so to speak. My prejudice is the overzealous nature of corporate and business schemes onto the matter (I mean wealthy people to have a vested interest in a long [prosperous] life but less publicly and for a totally different logic) along with the totalitarian trend of regimentation of society (The Typical Tyrants and Acolytes). I mean, if Jesus or Buddha (or some other Enlighted Soul) had the secret to longevity and wanted to enforce their Central Dogma, these latter characters would not even have an honorable mention. Or rather, why would good and humble people promote or even share something greater than Wealth and Power with those? I beg the pardon of the mice, but that scene was comical and exhilarating. I said premature because human clinical studies, if they exist, are guarded with the zeal of corporate secrecy and even Military (the inordinate power part) classified protection. This of course is the nonsense of current Investigations on Molecular Epigenetics.....Heil!

[channel deleted]
2023-01-22 08:33:50

The main thing I was focusing on was why Derek was filming while being filmed. Filmception?

Bill Kinsman
2023-01-22 07:35:52

No doubt, I want to live forever. !50 at least!

Justin Stebbings
2023-01-21 16:20:01

Wow I can see why you have so many followers. Im hooked on some of these videos already, which I've stumbled upon this afternoon. This is better than I remember educación being at school all those years ago.

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